J Med Allied Sci 2017; 7(1):64-66 DOI: https://doi.org/10.5455/jmas.249352
Unusual case of stroke in young
Dhavala Aashitha1, T. Umesh1, Mohammed Aejaz Habeeb2
1Department of Neurology, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad-500058, Telangana, India.
2Department of Gastroenterology, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad-500058, Telangana, India.
Corresponding author: Dr. Tukaram Umesh, Professor, Department of Neurology, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad-500058, Telangana, India.
Phone: +91-9248033372 Email: email@example.com
Thromboembolism is a rare extra-intestinal manifestation of inflammatory bowel disease. Thromboembolic event involving CNS in a case with inflammatory bowel disease (IBD) is very rare & leads to increase in mortality. The mortality of ulcerative colitis with thromboembolic complications have been reported to reach 25 percent. Here, we present a case of a young adult with a two years old history of ulcerative colitis with a sudden onset of stroke with no other associated co-morbidities for cerebrovascular disease.
Keywords: Anticoagulation therapy, homocysteine, hypercoagulable states, stroke, thromboembolic event, ulcerative colitis
Running title: Stroke in ulcerative colitis
Ulcerative colitis (UC) which is an inflammatory disease of the bowel rarely leads to thromboembolic complications which lead increased mortality and morbidity. Deep vein thrombosis (DVT) and pulmonary thromboembolism are the most common thromboembolic complications in IBD cases1 whereas stroke and myocardial infarction are rare.
A 27 year old male patient visited to our hospital with recurrent abdominal pain, vomiting and bloody diarrhea of 2 years duration, earlier diagnosed as ulcerative colitis. During a week of hospitalization, the patient had transient loss of consciousness lasting for few minutes following which he developed sudden loss of power in right arm and leg with cessation of speech and deviation of angle of his mouth towards the left. He did not have significant family history.
His blood pressure recorded was 110/80 mm Hg, heart rate was 88 beats/min and normal temperature. He had pallor, grade 2 clubbing and pitting edema of right leg. Neurologically, he was conscious, alert, comprehending with reduced word output. He had right facial weakness with grade 0-1 power in right limbs.
Detailed biochemical investigations revealed low hemoglobin (8 gm/dl) with lower normal range platelet count (1.5 lakhs/cumm), normal total leukocyte count (8,000 cells/cumm). Hypercoagulability work up revealed raised partial thromboplastin time (PTT), raised prothrombin time/international normalized ratio (PT/INR), reduced protein-C, reduced factor V and reduced antithrombin III levels. Antinuclear antibodies (ANA) levels were within normal limits. Ultrasonography showed mild to moderate ascites with hepatomegaly and portal hypertension. Echocardiogram was normal. Colonoscopy showed multiple healing ulcers (Fig 1). Computed tomography of brain revealed left side middle cerebral artery (MCA) cortical infarct (Fig 2).
Fig 1. Colonoscopy (A) Ascending colon showing few scattered ulcers in healing phase with normal intervening mucosa and (B) Transverse colon showing multiple healing pseudopolyps and few healing ulcers - Early remission phase of ulcerative colitis
Fig 2. CT Brain (Plain) showing infarct in left parieto-temporal region
The patient was given blood transfusions to compensate his ongoing blood loss. He was given anticoagulants, aspirin, statins, ACE inhibitors and cerebroprotein hydrolysate. Patient was hospitalized for 2 weeks; during his stay he did not show any signs of improvement but left with residual right hemiplegia subsequently. Patient was discharged advising rehabilitation program.
The association of inflammatory bowel disease (IBD) with thrombosis was first described by Bargen and Baker in 19362. Four decades later it was Patterson, who described thromboembolic event involving central nervous system (CNS) in a child with IBD3. During 1970-1980 a study revealed thromboembolic complications in 92 cases (1.3 %) among 7,199 cases with IBD4. Thromboembolic events involving CNS in IBD patients are unusual and devastating. Arterial thromboembolisms are rare. Reports claim that two thirds of thromboemboli are venous and one third are arterial5. Houissa et al described arterial thrombosis in 4 cases, 3 of them younger than 25 years6. Arterial thromboembolisms are usually post surgery cases.
Ulcerative colitis (UC) cases are reported to be more commonly complicated with thromboembolic events. Pan-colonic disease has been reported as a major risk factor for stroke7. Women are reported to be effected more than men; this could be due to the use of oral contraceptives. Stroke usually occurs during the active stage of IBD in young adults or during gastrointestinal (GI) complications like abscess or fistula8.
Thromboembolism associated with IBD usually presents with early atherosclerosis and increased homocysteine9. Hyperhomocysteinemia associated with increased thrombosis is due to increase in factor V, factor VIII and platelet abnormalities10. Increased homocysteine levels are associated with vitamin B6 , vitamin B12 and folate deficiency which are involved in homocysteine metabolism while vitamin D deficiency could be due to malabsorption or reduced dietary intake .
Inherited hypercoagulable states were reported to be a cause of stroke11. High prevalence of thrombosis in IBD case could be associated with hereditary factors such as methylene tetrahydrofolate reductase (MTHFR), factor V, prothrombin gene mutation, antithrombin III deficiency, protein C and protein S abnormalities. Our case had reduced protein C levels, raised PTT and PT/INR.
In IBD cases, aggregation of platelets in mesenteric vessels leads to release of platelet activating factor and thromboxane production leading to further thrombus formation.
Association of maternal active ulcerative colitis with fetal infarcts was reported by Scher12. Consideration of other co-morbidities such as sepsis, post surgery, immobility, contraception, smoking, obesity, etc should be done.
Thromboembolic events should not be overlooked in cases with IBD and prophylactic treatment should be given. Prophylactic alteration in modifiable risk factors such as smoking, obesity, diet, contraception should be done. Anticoagulation therapy should be started in high risk cases13. While use of low molecular weight heparins (LMWH) are still under debate14. Few reports suggest the use of TNF inhibitors as pro-inflammatory cytokines TNF and IL-6 are said to be increased in these patients15. Prophylactic protocolectomy has been reported to prevent thromboembolic events in IBD cases while few reports deny it.
Conflict of interest: None
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