E-ISSN 2231-170X | ISSN 2231-1696
 

Review Article 


Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis

Nazima Begum, Syed Mohammed Akbar Hassan, Purushottam Padmanabhan, Shaik Iqbal Ahmed, Avinash Bardia, Aleem Ahmed Khan.

Abstract
It has been estimated that 4.4 billion individuals are infected with Helicobacter pylori and the prevalence of the infection varies globally ranging from the highest reported in Africa (70.1%) to lowest in Switzerland (18.9%). The prevalence is still abundant in developing countries and is due to the outcome of low socioeconomic status and poor sanitation. Helicobacter pylori infection is implicated in several pathological states and is confronting a gigantic challenge to the global health community. This review provides an extensive picture of Helicobacter pylori infection prevalence and its association with disease outcomes using myriad sample studies, emphasizing detection using gastric biopsy. Moreover novel molecular mechanisms unveiled to date are also presented to better comprehend the underlying events that triggers the epidemiological effects. Data and mechanistic pathways presented in this review aid in improved regulation of Helicobacter pylori infection and assists in designing and crafting new drugs to treat the associated clinical conditions.

Key words: miRNA, Cancer, H.pylori, CagA


 
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How to Cite this Article
Pubmed Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci. 2021; 11(2): 105-113. doi:10.5455/jmas.49688


Web Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. https://jmas.in/?mno=49688 [Access: December 04, 2023]. doi:10.5455/jmas.49688


AMA (American Medical Association) Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci. 2021; 11(2): 105-113. doi:10.5455/jmas.49688



Vancouver/ICMJE Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci. (2021), [cited December 04, 2023]; 11(2): 105-113. doi:10.5455/jmas.49688



Harvard Style

Begum, N., Hassan, . S. M. A., Padmanabhan, . P., Ahmed, . S. I., Bardia, . A. & Khan, . A. A. (2021) Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci, 11 (2), 105-113. doi:10.5455/jmas.49688



Turabian Style

Begum, Nazima, Syed Mohammed Akbar Hassan, Purushottam Padmanabhan, Shaik Iqbal Ahmed, Avinash Bardia, and Aleem Ahmed Khan. 2021. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. Journal of Medical and Allied Sciences, 11 (2), 105-113. doi:10.5455/jmas.49688



Chicago Style

Begum, Nazima, Syed Mohammed Akbar Hassan, Purushottam Padmanabhan, Shaik Iqbal Ahmed, Avinash Bardia, and Aleem Ahmed Khan. "Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis." Journal of Medical and Allied Sciences 11 (2021), 105-113. doi:10.5455/jmas.49688



MLA (The Modern Language Association) Style

Begum, Nazima, Syed Mohammed Akbar Hassan, Purushottam Padmanabhan, Shaik Iqbal Ahmed, Avinash Bardia, and Aleem Ahmed Khan. "Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis." Journal of Medical and Allied Sciences 11.2 (2021), 105-113. Print. doi:10.5455/jmas.49688



APA (American Psychological Association) Style

Begum, N., Hassan, . S. M. A., Padmanabhan, . P., Ahmed, . S. I., Bardia, . A. & Khan, . A. A. (2021) Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. Journal of Medical and Allied Sciences, 11 (2), 105-113. doi:10.5455/jmas.49688