E-ISSN 2231-170X | ISSN 2231-1696
 

Original Article
Online Published: 07 Dec 2015
 


Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar.


Abstract
Fluoride is known to cross the blood-brain barrier and alter the structure and function of neural tissue. There are few authoritative reports on neurodegenerative changes in hippocampus, neocortex, cerebellum, spinal cord and sciatic nerve in fluoride intoxication. We report the alterations in the structure of neuronal tissue after chronic administration of sodium fluoride (for 60days) to rats. Twelve male Wistar rats were divided equally into two groups: one group received 20 ppm of sodium fluoride (NaF) and the other group (which served as a control) received tap water for 60days.
The body weights and organic somatic index of brain in the sodium fluoride treated animals were significantly reduced, relative to the control group. Tissue fluoride levels of hippocampus, neocortex, cerebellum, spinal cord and sciatic nerve, all increased significantly in fluoride treated rats. Electron microscopy of the hippocampus, neocortex, cerebellum, spinal cord and sciatic nerve showed neurodegenerative changes in the NaF treated group compared to controls. Axon deterioration, myelin sheath degeneration and dark cells with scanty cytoplasm were observed in spinal cord and sciatic nerve in the treated group. Other distinctive morphological alterations observed were: vacuolated swollen mitochondria in neocortex, hippocampus and cerebellum; myelinated fibers with breaks in continuity (axon partly preserved and partly vacuolated) in hippocampus; myelin splitting and vacuolated schwann cell within the cerebellum and sciatic nerve respectively. Thus, neurodegeneration was clearly evident in the hippocampus, neocortex, cerebellum, spinal cord and sciatic nerve on fluoride exposure.

Key words: Sciatic nerve, Cerebellum, Sodium fluoride, Hippocampus, Transmission electron microscope


 
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How to Cite this Article
Pubmed Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar. Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride. J Med Allied Sci. 2011; 1(1): 30-35.


Web Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar. Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride. https://jmas.in/?mno=210079 [Access: September 12, 2024].


AMA (American Medical Association) Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar. Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride. J Med Allied Sci. 2011; 1(1): 30-35.



Vancouver/ICMJE Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar. Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride. J Med Allied Sci. (2011), [cited September 12, 2024]; 1(1): 30-35.



Harvard Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar (2011) Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride. J Med Allied Sci, 1 (1), 30-35.



Turabian Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar. 2011. Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride. Journal of Medical and Allied Sciences, 1 (1), 30-35.



Chicago Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar. "Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride." Journal of Medical and Allied Sciences 1 (2011), 30-35.



MLA (The Modern Language Association) Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar. "Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride." Journal of Medical and Allied Sciences 1.1 (2011), 30-35. Print.



APA (American Psychological Association) Style

P. Yugandhar Reddy, K. Pratap Reddy, K. Praveen Kumar (2011) Neurodegenerative changes in different regions of brain, spinal cord and sciatic nerve of rats treated with sodium fluoride. Journal of Medical and Allied Sciences, 1 (1), 30-35.