E-ISSN 2231-170X | ISSN 2231-1696
 

Original Article 


Pattern of dyslipidemia in ischemic stroke

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash.

Abstract
The study aimed to assess dyslipidemia pattern including role of non HDL cholesterol (non HDLc) in ischemic strokes. A retrospec-tive descriptive was conducted on 80 patients who were admitted to Osmania General Hospital between May 2013 and May 2015 with new onset of stroke. A detailed history, physical examination and outcome details were collected from the hospital medical rec-ords. Data such as fasting lipid profile was noted, non HDLc was calculated, computed tomography (CT) or magnetic resonance imaging (MRI) brain reports were collected from medical records. Among enrolled patients, 55 were males and 25 were females. Age distribution: <40 years, n=4; 40-60 years, n=50; and >60 years, n=26. Dyslipidemia as per ATP III guidelines was present in 92.5% cases (n = 74). In our study, high LDL was found in 16 cases (21.62%), high total cholesterol in 16 cases (21.6%), low HDL in 57 cases (77%), high triglycerides in 13 cases (17.56%) and elevated non HDLc (>130mg/dl) in 28 patients (37.8%). Risk factors for stroke present were hypertension (n=48, 60%), diabe-tes (n=18, 22.5%), both diabetes and hypertension (n=15, 18.75%), smoking (n=33, 41.25%), alcoholism (n=32, 40%) and more than 2 risk factors were present in 28.75% (n=23). Total number of deaths was 05%. To conclude, most of the patients were having low HDL (<40mg/dL) which is an independent risk factor for stroke. This study also highlights the importance of ele-vated non HDL Cholesterol in development of ischemic stroke, which is more comprehensive measure of atherogenic lipoprotein than LDL cholesterol alone. This study upholds the importance of life style modifications to cut down the risk of development of stroke and also to evaluate the association between elevated non-HDL cholesterol in stroke patients.

Key words: Dyslipidemia, stroke, Low Density Lipoprotein cholesterol (LDL c), High Density, Lipoprotein cholesterol (HDL c), non HDL cholesterol


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ravala Siddeswari
Articles by Siddula Manohar
Articles by Budithi Sudarsi
Articles by Barla Suryanarayana
Articles by P. Shravan Kumar
Articles by Thatikala Abhilash
on Google
on Google Scholar

REFERENCES
1. Dalal PM. API Text Book of Medicine. Jaypee Brother's Publications, Vol 2, 19th Edition, Ch 20.8, pg 1401, 2012.
2. Cerebrovascular diseases, Ch 34, In: Adam's and Victor's Principles of Neurology, 7th edition, Maurice Victor, Allan Ropper (Eds), McGraw Hill publications, pg 821-919, 2001.
3. Smith WS, English JD, Johnston SC. Cerebrovascular Diseases. In: Harrison's text book of Medicine, 18th edition, vol 2 , Ch 370, pg 3270-3290.
4. Hirsch GA, Vaid N, Blumenthal RS. The Significance of measuring non-HDL Cholesterol. Preventive Cardiology. 2002; 5(3):156-159. [DOI via Crossref]    [Pubmed]   
5. Goldberg AC. Dyslipidemia (Hyperlipidemia). Merck Manual (Last full review/revision) September 2013.
6. Neurologic complications of hypertension. Ch 7 Anthony S. Kim, Clay Johnston Aminoff's Neurology and General medicine 334:1216, 1996.
7. Stroke fact sheet India. [Accessed 21 July 2013]. http://www.sancd.org/Updated%20Stroke%20Fact%20sheet%202012.pdf.
8. Central Bureau of Health Intelligence. National Health Profile. New Delhi: Directorate General of Health Sci-ences, 2008:102
9. World Health Organization. Workshop Report on Stroke Surveillance in India. (Last checked 28 June 2012)
10. Goldstein LB, Adams R, Becker K, Furberg CD, Gorelick PB, Hademenos G et al. Primary Prevention of Ischemic Stroke: A Statement for Healthcare Professionals from the Stroke Council of the American Heart Association. Circulation. 2001; 103:163 [DOI via Crossref]    [Pubmed]   
11. Nicholls S and Lundman P. The emerging role of lipoproteins in atherogenesis: beyond LDL cholesterol. Semin Vasc Med. 2004; 4:187-195. [DOI via Crossref]    [Pubmed]   
12. Wild SH, Byrne CD, Tzoulaki I, et al. Metabolic syndrome, haemostatic and inflammatory markers, Cerebrovascular and peripheral arterial disease: The Edinburgh Artery Study. Atherosclerosis. 2009; 203:604-609. [DOI via Crossref]    [Pubmed]   
13. Rodriguez-Colon SM, Mo J, Duan Y, et al. Metabolic syndrome clusters and the risk of incident stroke: the atherosclerosis risk in communities (ARIC) study. Stroke. 2009; 40:200-205. [DOI via Crossref]    [Pubmed]   
14. Hirsch GA, Vaid N, Blumenthal RS. The significance of measuring non-HDL cholesterol. Preventive Cardiology. 2002; 5(3): 156-159. [DOI via Crossref]    [Pubmed]   
15. Jia L, Bai H, Fu M, Xu Y, Yang Y, Long S. Relationship between plasma HDL subclasses distribution and apoA-I gene polymorphisms. Clinica Chimica Acta 2005; 360:37-45. [DOI via Crossref]    [Pubmed]   
16. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) (Adult Treatment Panel III). JAMA. 2001; 285: 2486-97. [DOI via Crossref]   
17. Vascular Diseases of the Nervous System Ischemic Cerebrovascular Disease, José Biller, Betsy B. Love, Michael J. Schneck Bradley's neurology in clinical practice 6th edition, vol 1, Elsever Saunders, Ch 51 A,1003-1010.
18. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) (Adult Treatment Panel III). JAMA. 2001; 285: 2486-2497. [DOI via Crossref]   
19. Cynthia A, Yogeesha KS, et al Dyslipedemia in stroke IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) 2014; 13(4):45-49.
20. Sridharan R. Risk factors for ischemic stroke: a case control analysis. Neuroepidemiology.1992; 11:24-30. [DOI via Crossref]    [Pubmed]   
21. Tirschwell DL, Smith NL, Heckbert SR, Lemaitre RN, Longstreth Jr. WT, Psaty BM. Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups. Neurology. 2004; 63: 1868-1875. [DOI via Crossref]    [Pubmed]   
22. Xingang Z, Zhaoqing S, Xinzhong Z, Liqiang Z, Shuangshuang L, Changlun X, et al. Gender differences in blood lipids and the risk of ischemic stroke among the hypertensive adults in rural China. Neurology India. 2007; 55:338-3 42.

How to Cite this Article
Pubmed Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash. Pattern of dyslipidemia in ischemic stroke. J Med Allied Sci. 2015; 5(2): 26-29.


Web Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash. Pattern of dyslipidemia in ischemic stroke. https://jmas.in/?mno=209747 [Access: January 12, 2023].


AMA (American Medical Association) Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash. Pattern of dyslipidemia in ischemic stroke. J Med Allied Sci. 2015; 5(2): 26-29.



Vancouver/ICMJE Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash. Pattern of dyslipidemia in ischemic stroke. J Med Allied Sci. (2015), [cited January 12, 2023]; 5(2): 26-29.



Harvard Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash (2015) Pattern of dyslipidemia in ischemic stroke. J Med Allied Sci, 5 (2), 26-29.



Turabian Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash. 2015. Pattern of dyslipidemia in ischemic stroke. Journal of Medical and Allied Sciences, 5 (2), 26-29.



Chicago Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash. "Pattern of dyslipidemia in ischemic stroke." Journal of Medical and Allied Sciences 5 (2015), 26-29.



MLA (The Modern Language Association) Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash. "Pattern of dyslipidemia in ischemic stroke." Journal of Medical and Allied Sciences 5.2 (2015), 26-29. Print.



APA (American Psychological Association) Style

Ravala Siddeswari, Siddula Manohar, Budithi Sudarsi, Barla Suryanarayana, P. Shravan Kumar, Thatikala Abhilash (2015) Pattern of dyslipidemia in ischemic stroke. Journal of Medical and Allied Sciences, 5 (2), 26-29.