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2021, Vol: 11, Issue: 2
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Review Article 


Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari.

Abstract
The recent decades have witnessed an alarming increase in the Helicobacter pylori associated diseases worldwide. In spite of this, deficiencies in our knowledge still exist about its exact epidemiology, the optimum method of its diagnosis and indeed about the precise role it plays in gastric carcinogenesis. In the present article, we review the available literature in an attempt to assign a definite role to this unique gastric pathogen. The acquisition of the cag-PAI has undoubtedly altered the understanding of host-microbe interactions, and growing appreciation of other potential determinants viz: vacA, iceA, babA, hrgA etc., may en-able us understand the role of this organism and its gradual transition from a commensal to a pathogen.

Key words: Helicobacter pylori, commensal, pathogen


 
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REFERENCES
1. Farthing MJ. Helicobacter pylori infection: an overview. Br Med Bull 1998; 54:1-6. [DOI via Crossref]    [Pubmed]   
2. Schistomes, Liver flukes and Helicobacter pylori. IARC working group on the evaluation of carcinogenic risks to humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum, 61:1-241, 1994. [Pubmed]   
3. Maeda S, Kanai F, Ogura K, et al. High seropositivity of anti-CagA antibody in Helicobacter pylori-infected patients irrelevant to peptic ulcers and normal mucosa in Japan. Dig Dis Sci 1997; 42:1841-1847. [DOI via Crossref]    [Pubmed]   
4. Khulusi S, Mendall MA, Patel P, et al. Helicobacter pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects. Gut 1995; 37:319-324. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. Lieber CS, Puspok A, Oberhuber G, et al. Helicobacter pylori and Non-Ulcer Dyspepsia. N Engl J Med 1999; 340: 1508-1511. [DOI via Crossref]    [Pubmed]   
6. Smith K and Parsonnet J. In: Bacterial infections of Humans: Epidemiology and control. A. S. Evans and P. S. Branchman (Eds), Plenum, New York, pp.337-353, 1998. [DOI via Crossref]    [PMC Free Fulltext]   
7. Ahmed KS, Khan AA, Ahmed I, et al. Prevalence study to elucidate the transmission pathways of Helicobacter pylori at oral and gastro-duodenal sites of a South Indian population. Singapore Med J 2006; 47(4):291-296. [Pubmed]   
8. Leal-Herrera Y, Torres J, Monath JP, et al. High rates of recurrence and of transient reinfections of Helicobacter pylori in a population with high prevalence of infection. Am J Gastroenterol 2003; 98:2395-2402. [DOI via Crossref]    [Pubmed]   
9. Linz B, Balloux F, Moodley Y, et al. An African origin for the intimate association between humans and Helicobacter pylori. Nature 2007; 445(7130):915-918. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Blaser MJ. Helicobacters are indigenous to the human stomach-duodenal ulceration is due to changes in gastric microecology in the modern era. Gut 1998; 43:721-727. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
11. Blaser MJ. Science Medicine, and the future-Helicobacter pylori and gastric diseases. Br Med J 1998; 316:1507-1510. [DOI via Crossref]   
12. Lee A. Helicobacter pylori is pathogenic flora. In: Helicobacter pylori: Basic mechanisms to clinical cure. Academic Medical Centre, Amsterdam, The Netherlands, pp.31, 2000. [DOI via Crossref]    [PMC Free Fulltext]   
13. Levin BR. The evolution and maintenance of virulence in microparasites. Emerg Infect Dis 1996; 2:93-102. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
14. Susser M and Stein Z. Civilization and peptic ulcer. Lancet 1962; i: 115-119.
15. Kato I, Nomura A, Stemmerman GN, et al. A prospective study of diet gastric and duodenal ulcer and its relation to smoking, alcohol, and diet. Am J Epidemiol 1992; 135:521-530. [Pubmed]   
16. Kauser F, Khan AA, Hussain MA, et al. The cag patho-genicity island (cag-PAI) of Helicobacter pylori is disrupted in majority of patient isolates from different human populations. J Clin Microbiol 2004, 42: 5302-5308. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
17. Ahmed N, Khan AA, Alvi A, et al. Genomic analysis of Helicobacter pylori from Andhra Pradesh, South India: Molecular evidence for three major genetic clusters. Curr Sci 2003; 85:101-108.
18. Lu H, Hsu PI, Graham DY, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterol 2005; 128:833-848. [DOI via Crossref]   
19. El-Omar E, Peaman I, Dorrian CA, Ardrill JE, McColl KE. Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcers. Gut 1993; 34: 1060-1065. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
20. Maltsson A, Lonroth H, Quiding-Jarbrink M, Svennerholm AM. Induction of B-cell responses in the stomach of Helicobacter pylori-infected after oral cholera vaccination. J Clin Invest 1998; 102:51-56. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
21. Censini S, Lange C, Xiang Z, et al. cag, A pathogenicity island of Helicobacter pylori, encodes type-I specific and disease- associated virulence factors. Proc Natl Assoc Sci 1996; 93:14648-14653. [DOI via Crossref]   
22. Odenbreit S, Puls J, Sedlmaier B, et al. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 2000; 287:1497-1500. [DOI via Crossref]    [Pubmed]   
23. Tiwari SK, Manoj G, Kumar GV, et al. Prognostic significance of genotyping Helicobacter pylori infection in patients in younger age groups with gastric cancer. Postgrad Med J 2008; 84(990):193-197. [DOI via Crossref]    [Pubmed]   
24. Lu H, Graham DY, Yamaoka Y. The Helicobacter pylori restriction endonuclease replacing Gene, hrgA and clinical outcome: Comparison of East Asia and western countries. Dig Dis Sci 2004; 49(9):1551-1555. [DOI via Crossref]    [Pubmed]   
25. Bulent K, Murat A, Esin A, et al. Association of cagA with vacA presence with ulcer and non-ulcer dyspepsia in a Turkish population. World J Gastroenterol 2003; 9(7):1580-1583. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

How to Cite this Article
Pubmed Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari. Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”. J Med Allied Sci. 2011; 1(1): 2-6.

Web Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari. Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”. https://jmas.in/?mno=210040 [Access: January 12, 2023].

AMA (American Medical Association) Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari. Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”. J Med Allied Sci. 2011; 1(1): 2-6.


Vancouver/ICMJE Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari. Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”. J Med Allied Sci. (2011), [cited January 12, 2023]; 1(1): 2-6.


Harvard Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari (2011) Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”. J Med Allied Sci, 1 (1), 2-6.


Turabian Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari. 2011. Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”. Journal of Medical and Allied Sciences, 1 (1), 2-6.


Chicago Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari. "Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”." Journal of Medical and Allied Sciences 1 (2011), 2-6.


MLA (The Modern Language Association) Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari. "Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”." Journal of Medical and Allied Sciences 1.1 (2011), 2-6. Print.


APA (American Psychological Association) Style

Santosh K. Tiwari, Aleem A. Khan, Pratibha Nallari (2011) Helicobacter pylori: “A benign fellow traveler or an unwanted inhabitant”. Journal of Medical and Allied Sciences, 1 (1), 2-6.


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