E-ISSN 2231-170X | ISSN 2231-1696
 
2022, Vol: 12, Issue: 2
12 / 2Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Original Article 


Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma.

Abstract
Neurosteroids (NS) are considered important modulators of brain functions. Lindane a pesticide has been shown to affect the nervous system adversely. The present study was designed to explore the modulation of the effects of lindane on convulsions by Allopregnenalone (AP), and 4′-Chlorodiazepam (4′-CD), in both acute and chronic seizure models using Pentylenetetrazole (PTZ). We used acute and chronic models. In the acute model, seizures were induced by PTZ 90mg/kg, intra-peritoneal (i.p.) injection, while in the chronic model, kindling was induced by injecting PTZ 30 mg/kg sub-cutaneous(s.c) on alternate days three times in a week. Lindane produced augmented effect on convulsions by decreasing the onset of preclonic convulsions and increased duration of clonic convulsions. AP (2.5mg/kg, i.p) and 4′-CD (0.5mg/kg, i.p) were able to attenuate the effect of acute as well as chronic exposure of lindane. They significantly increased the onset and decreased the duration of convulsions in lindane-treated rats. These results conclusively demonstrate the efficacy of the neurosteroids in lindane-induced convulsions in both acute as well as chronic models. Thus, NS have a potential role as anticonvulsant in treatment of convulsions produced by pesticides like lindane.

Key words: Convulsions, Neurosteroids, Pesticides, PTZ


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Krishna Tanwar
Articles by Pramod K. Mediratta
Articles by Krishna K. Sharma
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma. Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats. J Med Allied Sci. 2014; 4(1): 17-21.

Web Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma. Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats. https://jmas.in/?mno=211737 [Access: December 04, 2023].

AMA (American Medical Association) Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma. Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats. J Med Allied Sci. 2014; 4(1): 17-21.


Vancouver/ICMJE Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma. Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats. J Med Allied Sci. (2014), [cited December 04, 2023]; 4(1): 17-21.


Harvard Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma (2014) Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats. J Med Allied Sci, 4 (1), 17-21.


Turabian Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma. 2014. Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats. Journal of Medical and Allied Sciences, 4 (1), 17-21.


Chicago Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma. "Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats." Journal of Medical and Allied Sciences 4 (2014), 17-21.


MLA (The Modern Language Association) Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma. "Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats." Journal of Medical and Allied Sciences 4.1 (2014), 17-21. Print.


APA (American Psychological Association) Style

Krishna Tanwar, Pramod K. Mediratta, Krishna K. Sharma (2014) Effect of Allopregnenalone (AP) and 4′-Chlorodiazepam (4′CD) on the Lindane-induced acute and chronic convulsive behavior in rats. Journal of Medical and Allied Sciences, 4 (1), 17-21.


Author LoginReviewer LoginAbout PublisherEditorial Review PolicyEditorial & Peer Review ProcessConflict of Interest PolicyAdvertising PolicyLicense InformationCopyright Information

About Journal of Medical and Allied Sciences

Welcome to the Journal of Medical and Allied Sciences (JMAS), an official international publication of Deccan College of Medical Sciences, for rapid publi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


By regular mail/speed post/courier

Dr. Kazi Mudabbir Ahmed
Editor, JMAS,
Deccan College of Medical Sciences,
DMRL ‘X’ Road, Kanchanbagh (PO),
Hyderabad-500 058, Telangana, India.

By email: editorialoffice@jmas.in

By phone: +91 40 24340225, 24340129

By Mobile: +91-8522828349

By fax: +91 40 24340235