E-ISSN 2231-170X | ISSN 2231-1696
| Case Report | | |
Schwannoma of the adrenal gland
Anunayi Jeshtadi, Neelima Govada, Shrinivas B. Somalwar, Soumya Nagulapally.  |  | | | Abstract
Visceral schwannomas are extremely rare and are usually discovered incidentally on USG/CT-Scan. Primary schwannomas of the adrenal gland are extremely uncommon. It has been theorized that they originate from Schwann cells that insulate the nerve fibers innervating the adrenal medulla. Histopathological examination coupled with immunohistochemistry provides the definitive diagnosis. A 55 year old normotensive female presented with pain in the right loin since 5 months. Her renal parameters were normal. Contrast enhanced computed tomography of abdomen showed a well delineated 6.5 x 5cms mass at upper pole of her right kidney. 24-hour urinary metanephrine was slightly elevated (3.07mg/24hrs). A decline in Serum cortisol levels was observed following a dexamethasone suppression test (18.89nmol/l). Histopathological examination revealed a spindle cell tumor. Immunohistochemistry showed strong and diffuse positive staining for S-100 with negative expression for CD-117, desmin, CD-34, HMB-45, synaptophysin, chromogranin, cytokeratin, and SMA. Ki-67 index was 2%.A diagnosis of cellular schwannoma of adrenal gland was confirmed. Key words: Adrenal gland, Immunohistochemistry, S-100, Schwannoma
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| REFERENCES |
| 1. Jakowski JD, Wakely PE, Jimenez RE. An uncommon type of adrenal incidentaloma: a case report of a schwannoma of the adrenal medulla with cytological, histological, and ultrastructural correlation. Ann Diagn Pathol. 2008; 12:356-361. [DOI via Crossref] [Pubmed] | | | | 2. Lau SK, Spagnolo DV, Weiss LM. Schwannoma of the adrenal gland: report of two cases. Am J Surg Pathol. 2006; 30(5):630-634. [DOI via Crossref] [Pubmed] | | | | 3. Woodruff JM KH, Louis DN, Scheithauer BW. Schwannoma. Lyon, France: IARC Press, 2000. | | | | 4. Korets R, Berkenblit R, Ghavamian R. Incidentally discovered adrenal schwannoma. JSLS. 2007; 11(1):113-115. [Pubmed] [PMC Free Fulltext] | | | | 5. Tˆarcoveanu E, Dimofte G, Bradea C, et al. Adrenal schwannoma. JSLS. 2009; 13(1):116-119. | | | | 6. Yaseen M and Mary GF. Adrenal schwannoma: A Rare type of adrenal incidentaloma. Arch Pathol Lab Med 2013; 137(7):1009-1014. [DOI via Crossref] [Pubmed] | | | | 7. Woodruff JM, Godwin TA, Erlandson RA, Susin M, Martini N. Cellular Schwannoma: a variety of Schwannoma sometimes mistaken for a malignant tumor. Am J Surg Pathol 1981; 5:733-744. [DOI via Crossref] [Pubmed] | | | | 8. Gazula S and Mammen KJ. Schwannoma with concomitant tuberculosis in the adrenal gland. Indian J Urol 2007; 23:469-470. [DOI via Crossref] [Pubmed] [PMC Free Fulltext] | | |
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