E-ISSN 2231-170X | ISSN 2231-1696
Case Report | | |
Cryoglobulin induced skin ulceration
Fatima Razvi.  |  | | | Abstract Lupus Erythematosus (LE) is a multi-organ auto-immune disease which results from complex interaction of genetic and environmental factors. The clinical spectrum ranges from minor cutaneous lesions to life threatening multi-organ dysfunction. The skin manifestations are variable and common and range from LE specific to LE non-specific cutaneous disease. Vasculitis is one of the most common non-specific skin lesion of Systemic lupus erythematosus (SLE) and appears as purpuric lesions, infarcts along lateral nail folds, peripheral gangrene, sub-cutaneous nodules and ulcers. Mixed cryoglobulinaemia (type II) is associated with connective tissue disorders including SLE. Skin manifestations are seen in 60-100% patients and are more common in females. The most common manifestation is palpable purpura of lower extremities seen in 30-100% which often is triggered in winter or on cold exposure. Skin infarction, hemorrhagic crusts and ulcers are seen in 25% of patients. Wide spread necrotic ulcers are seen in 10-25% of patients which are often exacerbated by cold. Key words: SLE, Skin ulcers, Cryoglobulins
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REFERENCES |
1. Fox RI, Fox CM. Autoimmune diseases of the skin. 3rd edition; 414. | | 2. Cryoglobulinaemia Reactions to cold. PM Dowd Rook's textbook. 7th edition; 23.16. | |
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