E-ISSN 2231-170X | ISSN 2231-1696
 

Original Article 


CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash.

Abstract
The present study aims serial four year assessment of CD4 cell response after initiation of anti-retroviral therapy (ART) in patients with HIV/AIDS attending Osmania General Hospital, Hyderabad. It was a retrospective hospital based observational study. We included 110 HIV/AIDS who were on ART. Data was collected over a period of 04 years from 2005 to 2008 in the ART Centre, Upgraded Department of General Medicine, Osmania General Hospital. Data regarding CD4 cell count over 4 years was assessed for mean CD4 cell count, trends, age and sex wise distribution. All patients were on ART as per National Aids Control Organisation (NACO) guidelines. Complete blood picture, serum creatinine, blood urea, serum electrolytes, liver function tests, sputum for acid fast bacilli, chest radiography, CD4 cell count in all patients, fine needle aspiration and biopsy (if necessary), magnetic resonance imaging (if necessary), computerized tomography (if necessary), colonoscopy (if necessary). The present study showed mean CD4 count improvement of 128.78 cells/mm3 after 6 months of initiation of ART, 24.77cells /mm3 after 1 year, additional 67.53 cells/mm3 after 2nd year and after 3rd year 5.59cells/mm3 from base line CD4 cell count. Improvement in CD4 count was almost equal in both male and female and in age group <25 years and above 40 years age group also. Mean CD4 cell count improvement of 240.31 cells/mm3 in females and 220.54 cells/mm3 in males to the baseline after 3 years of treatment with ART. Present study clearly shows definite improvement in CD4 cell count after ART was more than 100% irrespective of age and sex. Regular intake of drugs will improve immunologic response. Therefore strict adherence to ART /regular counseling sessions at ART centres should be stressed upon.

Key words: Anti-retroviral therapy, CD4 count, HIV, National Aids Control Organisation


 
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REFERENCES
1. Gulick RM. Antiretroviral therapy of Human Immunodeficiency Virus and Acquired Immuno Deficiency Syndrome. In: Goldman L, Schafer AI, editors, Goldman-Cecil Medicine, 25th ed, Vol 2, Philadelphia, PA: Elsevier/Saunders, 2016.
2. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011; 365(6):493-505. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
3. Severe P, Juste MA, Ambroise A, Eliacin L, Marchand C, Apollon S, Edwards A, Bang H, Nicotera J, Godfrey C, Gulick RM, Johnson WD Jr, Pape JW, Fitzgerald DW.Early versus standard antiretroviral therapy for HIVinfected adults in Haiti. N Engl J Med. 2010; 363(3):257- 265. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
4. Grassly NC, Morgan M, Walker N, Garnett G, Stanecki KA, Stover J, Brown T, Ghys PD. Uncertainty in estimates ofHIV/AIDS: the estimation and application of plausibility bounds. Sex Transm Infect 2004; 80(Suppl 1):i31–i38. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. World Health Organization. Progress report 2011: Global HIV/AIDS response. Available from http://www.who.int/hiv/pub/progress_report2011/en/ (Last accessed on December 21, 2011).
6. UNAIDS. World AIDS Day Report 2011. Available from http://www.unaids.org/en/media/unaids/contentassets/doc uments/unaidspublication/2011/JC2216_WorldAIDSday_re port_2011_en.pdf (Last accessed May 22, 2012).
7. World Health Organization. Towards universal access: Scaling up priority HIV/AIDS interventions in the health sector. Progress report 2009. Available from http://www.who.int/hiv/pub/tuapr_2009_en.pdf (Last accessed April 26, 2011).
8. Montaner JS, Hogg R, Wood E, Kerr T, Tyndall M, Levy AR, Harrigan PR. The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet 2006; 368(9534):531-536. [DOI via Crossref]   
9. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009; 373(9657):48- 57. [DOI via Crossref]   
10. Attia S, Egger M, Muller M, Zwahlen M, Low N. Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS 2009; 23(11):1397-404. [DOI via Crossref]    [Pubmed]   
11. Williams B, Wood R, Dukay V, Delva W, Ginsburg D, Hargrove J, Stander M, Sheneberger R, Montaner J, Welte A. Treatment as prevention: preparing the way. J Int AIDS Soc 2011; 14(Suppl 1):S6 [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
12. Fngman JJ, Sax PE. Human immunodeficiency virus and pulmonary infections treatment guidelines. In: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM, Siegel MD, editors. Fishman's Pulmonary Diseases and Disorders, Vol 1, Chapter 123, New York, NY: McGraw Hill Education, pp.2242-2264, 2008.
13. Patel AK, et al. HIV and AIDS. In: The Association of Physicians of India. API Textbook of Medicine, 7 th ed, Chapter 5, pp.154-155, 2006.
14. Ravi V, Desai A, et al. Immunology of HIV Infection. In: The Association of Physicians of India. API Textbook of Medicine, 9 th ed, pp.1014-1016, 2012.
15. Lifson AR, Krantz EM, Eberly LE, Dolan MJ, Marconi VC, Weintrob AC, Crum-Cianflone NF, Ganesan A, Grambsch PL, Agan BK; Infectious Disease Clinical Research Program (IDCRP) HIV Working Group. Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort. AIDS Res Ther 2011; 8(1):2. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
16. Panel on antiretroviral guidelines for adults and adolescents: Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services, USA, 2009,1-161
17. Thompson MA, Aberg JA, Cahn P, Montaner JS, Rizzardini G, Telenti A, Gatell JM, Gunthard HF, Hammer SM, Hirsch MS, Jacobsen DM, Reiss P, Richman DD, Volberding PA, Yeni P, Schooley RT, International AIDS Society-USA. Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS SocietyUSA Panel. JAMA 2010, 304(3):321-333. [DOI via Crossref]    [Pubmed]   
18. Wood R. Clinical features and management of HIV/AIDS. In: Farrar J, Hotez P, Junghanss T, Kang G, Lalloo D, White NJ, editors. Manson's Tropical Diseases, 23rd ed, Philadelphia, PA: Saunders Elsevier, pp.79-96, 2014. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
19. Hammer SGD, Havlir D, Klement, et al. Scaling up antiretroviral therapy in resource-limited settings: guidelines for a public health approach, 2003 revision. Geneva: World Health Organization; 2003.
20. National AIDS Control Organization (NACO). Policies & Guidelines. Available from http://www.naco.gov.in/NACO/About_NACO/Policy__Guid elines/ (Last accessed on October 20, 2015).

How to Cite this Article
Pubmed Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci. 2016; 6(2): 68-71. doi:10.5455/jmas.215189


Web Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. https://jmas.in/?mno=215189 [Access: January 12, 2023]. doi:10.5455/jmas.215189


AMA (American Medical Association) Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci. 2016; 6(2): 68-71. doi:10.5455/jmas.215189



Vancouver/ICMJE Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci. (2016), [cited January 12, 2023]; 6(2): 68-71. doi:10.5455/jmas.215189



Harvard Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash (2016) CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci, 6 (2), 68-71. doi:10.5455/jmas.215189



Turabian Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. 2016. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. Journal of Medical and Allied Sciences, 6 (2), 68-71. doi:10.5455/jmas.215189



Chicago Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. "CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital." Journal of Medical and Allied Sciences 6 (2016), 68-71. doi:10.5455/jmas.215189



MLA (The Modern Language Association) Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. "CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital." Journal of Medical and Allied Sciences 6.2 (2016), 68-71. Print. doi:10.5455/jmas.215189



APA (American Psychological Association) Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash (2016) CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. Journal of Medical and Allied Sciences, 6 (2), 68-71. doi:10.5455/jmas.215189