E-ISSN 2231-170X | ISSN 2231-1696
 
2024, Vol: 14, Issue: 1
14 / 1Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Original Article
Online Published: 15 Oct 2023
 


Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis

Subhash Bhaskaran Pillai, Aneeta Mary Jacob, Sandhya K. Prathapan, Sneha Anna Joy, Jithu Kurian, Satheesh Balakrishnan, Sunil Rao Padmaraj, Reena Thomas.


Abstract
Central venous catheter-related blood stream infection (CRBSI) is a major cause of morbidity and mortality in patients on maintenance hemodialysis. The objective of the study was to assess the microbiology and clinical outcomes of CRBSI in patients on maintenance hemodialysis. This was a retrospective observational study of all the patients with Stage 5 chronic kidney disease on maintenance hemodialysis at Pushpagiri Medical College Hospital who developed CRBSI between 1st January 2019 and 31st December 2020. Out of the 105 CRBSI patients included in the study, 75% had diabetes mellitus while 95% had hypertension. The median time gap between central venous catheter (CVC) placement and CRBSI was found to be 22 days with a range of 3 days to 150 days. Fever was the most common clinical presentation of CRBSI while a few patients presented with encephalopathy and septic shock. The most commonly used empirical antibiotic was intravenous Cephalosporins. The most common micro-organism grown in culture was non-fermenting gram-negative rods (22.84%) followed by Staphylococcus aureus and Bacillus species. The success rate which was defined as resolution of symptoms without the need of modifying the antibiotic or change of CVC was 34.28%. 31% of patients required modification of antibiotic while 56.18% required change of CVC. Complications developed in 10.47% of patients, the most common being encephalopathy followed by septic shock. 5(4.7%) patients succumbed to complications while all others recovered completely. While treatment of CRBSI with empirical intravenous antibiotics alone was successful in only about one-third of the patients, culture-guided modification of antibiotic regimen with or without change of CVC, led to clinical improvement in the majority of cases.

Key words: Antibiotic, Central venous catheter-related blood stream infection, Chronic kidney disease, Hemodialysis


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Subhash Bhaskaran Pillai
Articles by Aneeta Mary Jacob
Articles by Sandhya K. Prathapan
Articles by Sneha Anna Joy
Articles by Jithu Kurian
Articles by Satheesh Balakrishnan
Articles by Sunil Rao Padmaraj
Articles by Reena Thomas
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Pillai SB, Jacob AM, Prathapan SK, Joy SA, Kurian J, Balakrishnan S, Padmaraj SR, Thomas R. Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis. J Med Allied Sci. 2022; 12(2): 70-75. doi:10.5455/jmas.27564

Web Style

Pillai SB, Jacob AM, Prathapan SK, Joy SA, Kurian J, Balakrishnan S, Padmaraj SR, Thomas R. Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis. https://jmas.in/?mno=27564 [Access: September 12, 2024]. doi:10.5455/jmas.27564

AMA (American Medical Association) Style

Pillai SB, Jacob AM, Prathapan SK, Joy SA, Kurian J, Balakrishnan S, Padmaraj SR, Thomas R. Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis. J Med Allied Sci. 2022; 12(2): 70-75. doi:10.5455/jmas.27564


Vancouver/ICMJE Style

Pillai SB, Jacob AM, Prathapan SK, Joy SA, Kurian J, Balakrishnan S, Padmaraj SR, Thomas R. Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis. J Med Allied Sci. (2022), [cited September 12, 2024]; 12(2): 70-75. doi:10.5455/jmas.27564


Harvard Style

Pillai, S. B., Jacob, . A. M., Prathapan, . S. K., Joy, . S. A., Kurian, . J., Balakrishnan, . S., Padmaraj, . S. R. & Thomas, . R. (2022) Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis. J Med Allied Sci, 12 (2), 70-75. doi:10.5455/jmas.27564


Turabian Style

Pillai, Subhash Bhaskaran, Aneeta Mary Jacob, Sandhya K. Prathapan, Sneha Anna Joy, Jithu Kurian, Satheesh Balakrishnan, Sunil Rao Padmaraj, and Reena Thomas. 2022. Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis. Journal of Medical and Allied Sciences, 12 (2), 70-75. doi:10.5455/jmas.27564


Chicago Style

Pillai, Subhash Bhaskaran, Aneeta Mary Jacob, Sandhya K. Prathapan, Sneha Anna Joy, Jithu Kurian, Satheesh Balakrishnan, Sunil Rao Padmaraj, and Reena Thomas. "Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis." Journal of Medical and Allied Sciences 12 (2022), 70-75. doi:10.5455/jmas.27564


MLA (The Modern Language Association) Style

Pillai, Subhash Bhaskaran, Aneeta Mary Jacob, Sandhya K. Prathapan, Sneha Anna Joy, Jithu Kurian, Satheesh Balakrishnan, Sunil Rao Padmaraj, and Reena Thomas. "Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis." Journal of Medical and Allied Sciences 12.2 (2022), 70-75. Print. doi:10.5455/jmas.27564


APA (American Psychological Association) Style

Pillai, S. B., Jacob, . A. M., Prathapan, . S. K., Joy, . S. A., Kurian, . J., Balakrishnan, . S., Padmaraj, . S. R. & Thomas, . R. (2022) Microbiology and clinical outcomes of central venous catheter-related blood stream infections in patients on maintenance hemodialysis. Journal of Medical and Allied Sciences, 12 (2), 70-75. doi:10.5455/jmas.27564


Author LoginReviewer LoginAbout PublisherEditorial Review PolicyEditorial & Peer Review ProcessConflict of Interest PolicyAdvertising PolicyLicense InformationCopyright Information

About Journal of Medical and Allied Sciences

Welcome to the Journal of Medical and Allied Sciences (JMAS), an official international publication of Deccan College of Medical Sciences, for rapid publi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


By regular mail/speed post/courier

Dr. Kazi Mudabbir Ahmed
Editor, JMAS,
Deccan College of Medical Sciences,
DMRL ‘X’ Road, Kanchanbagh (PO),
Hyderabad-500 058, Telangana, India.

By email: editorialoffice@jmas.in

By phone: +91 40 24340225, 24340129

By Mobile: +91-8522828349

By fax: +91 40 24340235