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Original Article
Online Published: 22 Dec 2015
 


Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance

Maimoona Mustafa, Syed Laeeq Ahmed.


Abstract
The objective of this study was to isolate pathogenic bacteria in neonatal septicaemia cases, and to know their antibiograms. Under aseptic precautions, blood was drawn from 140 neonates with suspected septicaemia and inoculated in brain heart infusion (BHI) broth. Isolates obtained were identified as per standard protocol and antibiotic susceptibility was done by Kirby Bauer disc diffusion method (as per CLSI guidelines). A total number of 62 (44.2%) patients had positive blood cultures. The most common pathogens isolated were Klebsiella pneumoniae (n=22, 35%) followed by Staphylococcus aureus (n=15, 24.1%), Escherichia coli (n=14, 22.5%), CONS (n=7, 11.2%) and Pseudomonas aeruginosa (n=4, 6.4%). The Gram negative organisms showed high resistance to commonly used antibiotics and were highly sensitive to Meropenem. The Gram positive bacteria showed high resistance to Ampicillin, Erythromycin and Amoxycillin; but they were highly susceptible to Linizolid and Vancomycin. As the Gram negative organisms were the most common isolates in neonatal septicemia, their resistance pattern should be considered essential for deciding the empirical treatment. Prompt treatment of neonatal sepsis with judicious use of appropriate antibiotics can minimize the morbidity and mortality, besides reducing the emergence of multi-drug resistant organisms in intensive care units (ICUs).

Key words: Coagulase negative Staphylococcus (CONS), Drug susceptibility, Early onset septicemia, Late onset septicemia, Neonatal septicemia


 
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Pubmed Style

Maimoona Mustafa, Syed Laeeq Ahmed. Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance. J Med Allied Sci. 2014; 4(1): 2-8.

Web Style

Maimoona Mustafa, Syed Laeeq Ahmed. Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance. https://jmas.in/?mno=211511 [Access: September 12, 2024].

AMA (American Medical Association) Style

Maimoona Mustafa, Syed Laeeq Ahmed. Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance. J Med Allied Sci. 2014; 4(1): 2-8.


Vancouver/ICMJE Style

Maimoona Mustafa, Syed Laeeq Ahmed. Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance. J Med Allied Sci. (2014), [cited September 12, 2024]; 4(1): 2-8.


Harvard Style

Maimoona Mustafa, Syed Laeeq Ahmed (2014) Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance. J Med Allied Sci, 4 (1), 2-8.


Turabian Style

Maimoona Mustafa, Syed Laeeq Ahmed. 2014. Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance. Journal of Medical and Allied Sciences, 4 (1), 2-8.


Chicago Style

Maimoona Mustafa, Syed Laeeq Ahmed. "Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance." Journal of Medical and Allied Sciences 4 (2014), 2-8.


MLA (The Modern Language Association) Style

Maimoona Mustafa, Syed Laeeq Ahmed. "Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance." Journal of Medical and Allied Sciences 4.1 (2014), 2-8. Print.


APA (American Psychological Association) Style

Maimoona Mustafa, Syed Laeeq Ahmed (2014) Bacteriological profile and antibiotic susceptibility patterns in neonatal septicemia in view of emerging drug resistance. Journal of Medical and Allied Sciences, 4 (1), 2-8.


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