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Original Article
Online Published: 10 Aug 2016
 


CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash.


Abstract
The present study aims serial four year assessment of CD4 cell response after initiation of anti-retroviral therapy (ART) in patients with HIV/AIDS attending Osmania General Hospital, Hyderabad. It was a retrospective hospital based observational study. We included 110 HIV/AIDS who were on ART. Data was collected over a period of 04 years from 2005 to 2008 in the ART Centre, Upgraded Department of General Medicine, Osmania General Hospital. Data regarding CD4 cell count over 4 years was assessed for mean CD4 cell count, trends, age and sex wise distribution. All patients were on ART as per National Aids Control Organisation (NACO) guidelines. Complete blood picture, serum creatinine, blood urea, serum electrolytes, liver function tests, sputum for acid fast bacilli, chest radiography, CD4 cell count in all patients, fine needle aspiration and biopsy (if necessary), magnetic resonance imaging (if necessary), computerized tomography (if necessary), colonoscopy (if necessary). The present study showed mean CD4 count improvement of 128.78 cells/mm3 after 6 months of initiation of ART, 24.77cells /mm3 after 1 year, additional 67.53 cells/mm3 after 2nd year and after 3rd year 5.59cells/mm3 from base line CD4 cell count. Improvement in CD4 count was almost equal in both male and female and in age group <25 years and above 40 years age group also. Mean CD4 cell count improvement of 240.31 cells/mm3 in females and 220.54 cells/mm3 in males to the baseline after 3 years of treatment with ART. Present study clearly shows definite improvement in CD4 cell count after ART was more than 100% irrespective of age and sex. Regular intake of drugs will improve immunologic response. Therefore strict adherence to ART /regular counseling sessions at ART centres should be stressed upon.

Key words: Anti-retroviral therapy, CD4 count, HIV, National Aids Control Organisation


 
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How to Cite this Article
Pubmed Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci. 2016; 6(2): 68-71. doi:10.5455/jmas.215189

Web Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. https://jmas.in/?mno=215189 [Access: September 12, 2024]. doi:10.5455/jmas.215189

AMA (American Medical Association) Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci. 2016; 6(2): 68-71. doi:10.5455/jmas.215189


Vancouver/ICMJE Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci. (2016), [cited September 12, 2024]; 6(2): 68-71. doi:10.5455/jmas.215189


Harvard Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash (2016) CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. J Med Allied Sci, 6 (2), 68-71. doi:10.5455/jmas.215189


Turabian Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. 2016. CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. Journal of Medical and Allied Sciences, 6 (2), 68-71. doi:10.5455/jmas.215189


Chicago Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. "CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital." Journal of Medical and Allied Sciences 6 (2016), 68-71. doi:10.5455/jmas.215189


MLA (The Modern Language Association) Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash. "CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital." Journal of Medical and Allied Sciences 6.2 (2016), 68-71. Print. doi:10.5455/jmas.215189


APA (American Psychological Association) Style

Srinivasa Rao Nanyam, Ravala Siddeswari, Budithi Sudarsi, Barla Suryanarayana, Challagali Prabhu Kumar, Thatikala Abhilash (2016) CD4 lymphocyte response following anti-retroviral therapy in HIV/AIDS patients - A study in Osmania General Hospital. Journal of Medical and Allied Sciences, 6 (2), 68-71. doi:10.5455/jmas.215189


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