E-ISSN 2231-170X | ISSN 2231-1696
 

Original Article
Online Published: 04 Feb 2019
 


Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae)

Paul Ngbede Olotu, Abubakar Ahmed, Oluyemisi Folashade Kunle, Ijeoma Adanma Olotu, Francis Maji Agwom, Ukpe Ajima.


Cited By: 1

Abstract
Cochlospermum planchonii is widely used in folk medicine in many Af-rican countries and has been shown to have beneficial activity in a number of disease conditions. The plant is proposed to contain anti-inflammatory compounds that can relieve pain and inflammation asso-ciated with elevated levels of prostaglandins in the body. The present study was therefore aimed at investigating the phytochemicals present in the methanolic extract of the leaves of Cochlospermum planchonii L. (Cochlospermaceae) and also evaluating the antioxidant and COX-1/COX-2 inhibitory activities of the extract. Antioxidant activity was de-termined using a 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay. Phyto-chemical evaluation performed using standard known methods re-vealed the presence of steroids/terpenes, cardiac glycosides, saponins, tannins, flavonoids and alkaloids. The extract had significant antioxidant activity of 93±0.11% in the DPPH assay. The extract was found to inhibit COX-2 selectively. The preliminary antioxidant screening indicated that the extract possesses the potential to scavenge free radicals and the capacity to bleach DPPH. The COX assay was carried out with a view to providing a simple mechanism by which the extract exhibits its anti-inflammatory action. The present results are consistent with the traditional use of this plant in phytotherapeutic preparations for managing pain and inflammation related ailments.

Key words: Cyclo-oxygenase inhibition, DPPH, Ethnopharmacology, Free radicals, Secondary metabolites


 
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How to Cite this Article
Pubmed Style

Olotu PN, Ahmed A, Kunle OF, Olotu IA, Agwom FM, Ajima U, . Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae). J Med Allied Sci. 2019; 9(1): 19-25. doi:10.5455/jmas.23465


Web Style

Olotu PN, Ahmed A, Kunle OF, Olotu IA, Agwom FM, Ajima U, . Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae). https://jmas.in/?mno=23465 [Access: September 12, 2024]. doi:10.5455/jmas.23465


AMA (American Medical Association) Style

Olotu PN, Ahmed A, Kunle OF, Olotu IA, Agwom FM, Ajima U, . Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae). J Med Allied Sci. 2019; 9(1): 19-25. doi:10.5455/jmas.23465



Vancouver/ICMJE Style

Olotu PN, Ahmed A, Kunle OF, Olotu IA, Agwom FM, Ajima U, . Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae). J Med Allied Sci. (2019), [cited September 12, 2024]; 9(1): 19-25. doi:10.5455/jmas.23465



Harvard Style

Olotu, P. N., Ahmed, . A., Kunle, . O. F., Olotu, . I. A., Agwom, . F. M., Ajima, . U. & (2019) Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae). J Med Allied Sci, 9 (1), 19-25. doi:10.5455/jmas.23465



Turabian Style

Olotu, Paul Ngbede, Abubakar Ahmed, Oluyemisi Folashade Kunle, Ijeoma Adanma Olotu, Francis Maji Agwom, Ukpe Ajima, and . 2019. Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae). Journal of Medical and Allied Sciences, 9 (1), 19-25. doi:10.5455/jmas.23465



Chicago Style

Olotu, Paul Ngbede, Abubakar Ahmed, Oluyemisi Folashade Kunle, Ijeoma Adanma Olotu, Francis Maji Agwom, Ukpe Ajima, and . "Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae)." Journal of Medical and Allied Sciences 9 (2019), 19-25. doi:10.5455/jmas.23465



MLA (The Modern Language Association) Style

Olotu, Paul Ngbede, Abubakar Ahmed, Oluyemisi Folashade Kunle, Ijeoma Adanma Olotu, Francis Maji Agwom, Ukpe Ajima, and . "Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae)." Journal of Medical and Allied Sciences 9.1 (2019), 19-25. Print. doi:10.5455/jmas.23465



APA (American Psychological Association) Style

Olotu, P. N., Ahmed, . A., Kunle, . O. F., Olotu, . I. A., Agwom, . F. M., Ajima, . U. & (2019) Phytochemical evaluation, antioxidant and COX-1 / COX-2 inhibitory activities of the methanol extract of the leaf of Cochlospermum planchonii Hook. F. (Cochlospermaceae). Journal of Medical and Allied Sciences, 9 (1), 19-25. doi:10.5455/jmas.23465