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Original Article
Online Published: 25 Jan 2017
 


Falciparum malaria associated changes in biochemical indices in children

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro.


Abstract
Metabolic disturbances associated with fluid and electrolyte imbalance, and changes in the synthetic functions of the liver are common complications of malaria and are dependent on the degree of parasitemia. Packed cell volume (PCV), random blood glucose (RBG), total bilirubin (TB), total proteins (TP), albumin, serum electrolytes [sodium (Na+), potassium (K+), chloride (Cl-), bicarbonate (HCO3-), calcium (Ca2+), magnesium (Mg2+)] and anion gap (AG) were determined in fifty children with malaria aged between 1-15 years and thirty age matched apparently healthy children without malaria, using colorimetric and flame photometric methods. Data was analyzed using t-test at p < 0.05. The PCV, RBG, Na+, Mg2+, AG and TP were significantly lower and Ca2+ and TB higher in children with malaria compared to children without malaria. The serum Na+, K+, AG, TP and albumin were significantly lower and Ca2+, HCO3- and TB higher in children with severe malaria compared to those with mild malaria. Malaria and high parasite density is associated with perturbations in homeostasis of proteins and electrolytes and these may be implicated in the deleterious consequences associated with malaria in children.

Key words: Billirubin, Children, Electrolytes, Malaria, Proteins


 
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How to Cite this Article
Pubmed Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro. Falciparum malaria associated changes in biochemical indices in children. J Med Allied Sci. 2017; 7(1): 29-33. doi:10.5455/jmas.253029

Web Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro. Falciparum malaria associated changes in biochemical indices in children. https://jmas.in/?mno=253029 [Access: September 12, 2024]. doi:10.5455/jmas.253029

AMA (American Medical Association) Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro. Falciparum malaria associated changes in biochemical indices in children. J Med Allied Sci. 2017; 7(1): 29-33. doi:10.5455/jmas.253029


Vancouver/ICMJE Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro. Falciparum malaria associated changes in biochemical indices in children. J Med Allied Sci. (2017), [cited September 12, 2024]; 7(1): 29-33. doi:10.5455/jmas.253029


Harvard Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro (2017) Falciparum malaria associated changes in biochemical indices in children. J Med Allied Sci, 7 (1), 29-33. doi:10.5455/jmas.253029


Turabian Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro. 2017. Falciparum malaria associated changes in biochemical indices in children. Journal of Medical and Allied Sciences, 7 (1), 29-33. doi:10.5455/jmas.253029


Chicago Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro. "Falciparum malaria associated changes in biochemical indices in children." Journal of Medical and Allied Sciences 7 (2017), 29-33. doi:10.5455/jmas.253029


MLA (The Modern Language Association) Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro. "Falciparum malaria associated changes in biochemical indices in children." Journal of Medical and Allied Sciences 7.1 (2017), 29-33. Print. doi:10.5455/jmas.253029


APA (American Psychological Association) Style

Augusta Chinyere Nsonwu-Anyanwu, Edmund Richard Egbe, Uloma Opara Osuoha, Paul Columba Inyang-Etoh, Sunday Jeremiah Offor, Chinyere Adanna Opara Usoro (2017) Falciparum malaria associated changes in biochemical indices in children. Journal of Medical and Allied Sciences, 7 (1), 29-33. doi:10.5455/jmas.253029


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