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Original Article
Online Published: 26 Jul 2018
 


The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats

Ikenna Kingsley Uchendu, Chidozie Elochukwu Agu, Oliver Chukwuma Orji.


Cited By: 2

Abstract
Acute pancreatitis is a relatively common disease with an estimated annual mortality rate of about 7%. Drug-use is a major etiological factor in the pathogenesis and pathophysiology of the condition. The aim of this study was to evaluate the effects of tomato extract on carbimazole-induced biochemical alterations in the pancreas of albino rats. phytochemical analysis of the tomato extract was done. A total of 24 male albino wistar rats weighing (225±25g) were randomly divided into 4 groups (A−D) with six rats per group. Group A served as the normal control group and received no treatment. Group B received only carbimazole (60mg/kg, oral) and served as the negative control group. Group C received vitamin C (200mg/kg, oral) and served as the positive control and Group D which served as test group received tomato extract (30mg/kg, oral) in the presence of carbimazole challenge for 4 weeks. Carbimazole administration to rats resulted in pancreatic damage with glucose, amylase, triglycerides and total protein levels: 126.33±6.64 mg/dl; 484.00±18.33 IU/L; 0.75±0.09 mmol/l and 4.83±0.12 g/dl respectively. The daily administration of tomato extract resulted in the mitigation of the carbimazole-induced pancreatic damage with glucose, amylase, triglyceride and total protein levels: 106.33±296 mg/dl (p˂0.01); 333.33±44.10 IU/L (p˂0.01); 2.80±0.31 mmol/l (p>0.05) and 6.33±0.44 g/dl (p>0.05) respectively. Tomato (Lycopersicon esculentum) possesses pancreas-protective property against carbimazole-induced pancreatic damage.

Key words: Acute pancreatitis, Albino rats, Carbimazole, Pancreatic protection, Tomato


 
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This Article Cited By the following articles

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Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats
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How to Cite this Article
Pubmed Style

Uchendu IK, Agu CE, Orji OC. The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats. J Med Allied Sci. 2018; 8(2): 59-65. doi:10.5455/jmas.285861

Web Style

Uchendu IK, Agu CE, Orji OC. The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats. https://jmas.in/?mno=285861 [Access: December 31, 2024]. doi:10.5455/jmas.285861

AMA (American Medical Association) Style

Uchendu IK, Agu CE, Orji OC. The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats. J Med Allied Sci. 2018; 8(2): 59-65. doi:10.5455/jmas.285861


Vancouver/ICMJE Style

Uchendu IK, Agu CE, Orji OC. The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats. J Med Allied Sci. (2018), [cited December 31, 2024]; 8(2): 59-65. doi:10.5455/jmas.285861


Harvard Style

Uchendu, I. K., Agu, . C. E. & Orji, . O. C. (2018) The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats. J Med Allied Sci, 8 (2), 59-65. doi:10.5455/jmas.285861


Turabian Style

Uchendu, Ikenna Kingsley, Chidozie Elochukwu Agu, and Oliver Chukwuma Orji. 2018. The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats. Journal of Medical and Allied Sciences, 8 (2), 59-65. doi:10.5455/jmas.285861


Chicago Style

Uchendu, Ikenna Kingsley, Chidozie Elochukwu Agu, and Oliver Chukwuma Orji. "The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats." Journal of Medical and Allied Sciences 8 (2018), 59-65. doi:10.5455/jmas.285861


MLA (The Modern Language Association) Style

Uchendu, Ikenna Kingsley, Chidozie Elochukwu Agu, and Oliver Chukwuma Orji. "The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats." Journal of Medical and Allied Sciences 8.2 (2018), 59-65. Print. doi:10.5455/jmas.285861


APA (American Psychological Association) Style

Uchendu, I. K., Agu, . C. E. & Orji, . O. C. (2018) The effects of tomato (Lycopersicon esculentum) extract on carbimazole-induced biochemical alterations in pancreas of albino rats. Journal of Medical and Allied Sciences, 8 (2), 59-65. doi:10.5455/jmas.285861


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