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2024, Vol: 14, Issue: 2
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Original Article
Online Published: 18 Mar 2024
 


Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis

Arijit Ghosh, Subhasis Ghosh, Shubhamitra Chaudhuri.


Abstract
The aim of the study was to analyze the intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short term prognosis. The present prospective study was conducted in the Department of Neurosurgery, Bangur Institute of Neurosciences and SSKM Hospital, IPGME and R, Kolkata from April 2020 to December 2021 in the Neurosurgery ward. 30 cases admitted in the department operated for suspected cases of intracranial and spinal ependymomas irrespective of any age groups and histologically confirmed thereafter by Pathology Department of SSKM hospital, IPGMER were included in the study. Age, sex, mode of presentation, clinical symptomatology, clinical findings, clinical, radiological investigations, surgical details, outcome data was recorded. The clinical follow-up observation was carried out by outpatient review. The patients were regularly followed up at 3, 6 and 12 months operation. Intracranial and spinal location was reported among 21 (70%) and 9 (30%) subjects respectively. During surgery, complete resection was achieved in 80% of the subjects. Out of 30 subjects, 90% of the subjects survived whereas mortality happened in 10% of the subjects. Most common complication was cranial nerve palsy (33.33%). The mean Ki-67 and p53 proliferative indices were significantly higher in grade III tumors as compared to grade II and grade I tumors. EMA was found to be positive in 70% of the subjects. The results concluded that p53 and Ki 67 indices when performed in routine diagnostic cases can supplement the histological diagnosis and at the same time these values could predict the relative difference in prognosis of various subtypes.

Key words: crania-spinal ependymomas, Immunohistochemical markers


 
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How to Cite this Article
Pubmed Style

Ghosh A, Ghosh S, Chaudhuri S. Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis. J Med Allied Sci. 2023; 13(1): 33-40. doi:10.5455/jmas.37154

Web Style

Ghosh A, Ghosh S, Chaudhuri S. Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis. https://jmas.in/?mno=37154 [Access: December 31, 2024]. doi:10.5455/jmas.37154

AMA (American Medical Association) Style

Ghosh A, Ghosh S, Chaudhuri S. Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis. J Med Allied Sci. 2023; 13(1): 33-40. doi:10.5455/jmas.37154


Vancouver/ICMJE Style

Ghosh A, Ghosh S, Chaudhuri S. Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis. J Med Allied Sci. (2023), [cited December 31, 2024]; 13(1): 33-40. doi:10.5455/jmas.37154


Harvard Style

Ghosh, A., Ghosh, . S. & Chaudhuri, . S. (2023) Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis. J Med Allied Sci, 13 (1), 33-40. doi:10.5455/jmas.37154


Turabian Style

Ghosh, Arijit, Subhasis Ghosh, and Shubhamitra Chaudhuri. 2023. Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis. Journal of Medical and Allied Sciences, 13 (1), 33-40. doi:10.5455/jmas.37154


Chicago Style

Ghosh, Arijit, Subhasis Ghosh, and Shubhamitra Chaudhuri. "Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis." Journal of Medical and Allied Sciences 13 (2023), 33-40. doi:10.5455/jmas.37154


MLA (The Modern Language Association) Style

Ghosh, Arijit, Subhasis Ghosh, and Shubhamitra Chaudhuri. "Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis." Journal of Medical and Allied Sciences 13.1 (2023), 33-40. Print. doi:10.5455/jmas.37154


APA (American Psychological Association) Style

Ghosh, A., Ghosh, . S. & Chaudhuri, . S. (2023) Prospective observational study of intracranial and spinal ependymomas with special reference to immunohistochemical markers in relation to short-term prognosis. Journal of Medical and Allied Sciences, 13 (1), 33-40. doi:10.5455/jmas.37154


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