E-ISSN 2231-170X | ISSN 2231-1696
 

Review Article
Online Published: 01 Aug 2020
 


Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species

Leta Melaku, Dheresa Worku.


Abstract
Free radicals are molecules with an unpaired electron, thus, they are highly reactive. The human body deals with the pathological effects of free radicals by utilizing antioxidant system. The concentration and location of reactive oxygen species (ROS) are the main determinants of their effect. A multitude of studies provide evidence that an uncontrolled production of ROS is involved in the development and progression of cardiovascular disease like atherosclerosis. Atherosclerosis is characterized by the formation of intimal plaques. Monitoring and rapid detection of oxidative stress markers is necessary to combat the spread of various diseases. Although there are several sources of vascular free radicals, the enzyme NADPH oxidase is emerging as a strong candidate for the excessive ROS production. Direct measurement of their cellular levels is therefore one approach to determine oxidative stress conditions.

Key words: Antioxidant, Atherosclerosis, Free radicals, Oxidative stress markers, ROS


 
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How to Cite this Article
Pubmed Style

Melaku L, Worku D. Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species. J Med Allied Sci. 2020; 10(2): 43-51. doi:10.5455/jmas.91137


Web Style

Melaku L, Worku D. Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species. https://jmas.in/?mno=91137 [Access: September 12, 2024]. doi:10.5455/jmas.91137


AMA (American Medical Association) Style

Melaku L, Worku D. Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species. J Med Allied Sci. 2020; 10(2): 43-51. doi:10.5455/jmas.91137



Vancouver/ICMJE Style

Melaku L, Worku D. Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species. J Med Allied Sci. (2020), [cited September 12, 2024]; 10(2): 43-51. doi:10.5455/jmas.91137



Harvard Style

Melaku, L. & Worku, . D. (2020) Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species. J Med Allied Sci, 10 (2), 43-51. doi:10.5455/jmas.91137



Turabian Style

Melaku, Leta, and Dheresa Worku. 2020. Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species. Journal of Medical and Allied Sciences, 10 (2), 43-51. doi:10.5455/jmas.91137



Chicago Style

Melaku, Leta, and Dheresa Worku. "Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species." Journal of Medical and Allied Sciences 10 (2020), 43-51. doi:10.5455/jmas.91137



MLA (The Modern Language Association) Style

Melaku, Leta, and Dheresa Worku. "Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species." Journal of Medical and Allied Sciences 10.2 (2020), 43-51. Print. doi:10.5455/jmas.91137



APA (American Psychological Association) Style

Melaku, L. & Worku, . D. (2020) Role of long term oxidative stress in pathobiology of atherosclerosis with evaluation of enzymes involved in the production of endogenous reactive oxygen species. Journal of Medical and Allied Sciences, 10 (2), 43-51. doi:10.5455/jmas.91137