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2023, Vol: 13, Issue: 1
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Original Article 


A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India

Rupanshu Mehra, Lalit Jain.

Abstract
In India, cardiovascular disease (CVD) is one of the leading causes of death. All subjects are not accurately predicted for risk of CVD by traditional risk factors. To improve the present risk prediction model, a search of novel biomarkers is required to recognize the risk of cardiovascular events. Novel biomarkers involved in inflammation cascade and developing atherosclerosis and coronary heart disease are of utmost importance. The objectives were to study high sensitivity C-reactive protein (hs-CRP), lipoprotein A and LDL/HDL cholesterol ratio in acute coronary syndrome (ACS) and its association with ACS severity. Eighty patients (aged 18-70 years of either sex) with ACS (diagnosed based on clinical history, clinical examination, electrocardiogram changes, and creatine phosphokinase-MB) were studied at a tertiary care hospital from 2017 to 2020. High sensitivity C-reactive protein (hs-CRP), lipoprotein A, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were estimated and the association was obtained. Incidence of ACS was seen highest in 56-65 years (28.75%) with males contributing 85% patients. The most common diagnosis was ST-elevation myocardial infarction (78.75%). The hs-CRP levels and lipoprotein A were increased in 49 and 44 patients out of 80, respectively. Patients with high hs-CRP (n=43 of 48; p<0.0001) and lipoprotein A (n=32 out of 48; p=0.026) at admission were prone for going into complications. High sensitivity-CRP and lipoprotein A levels obtained at admission in ACS patients can be used to identify patients who are likely to develop significant complications in the immediate in-hospital course and predict the prognosis.

Key words: Acute coronary syndrome, High sensitivity C-reactive protein, Lipoprotein A, Novel biomarkers


 
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Pubmed Style

Mehra R, Jain L. A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India. J Med Allied Sci. 2022; 12(2): 65-69. doi:10.5455/jmas.4045

Web Style

Mehra R, Jain L. A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India. https://jmas.in/?mno=4045 [Access: December 04, 2023]. doi:10.5455/jmas.4045

AMA (American Medical Association) Style

Mehra R, Jain L. A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India. J Med Allied Sci. 2022; 12(2): 65-69. doi:10.5455/jmas.4045


Vancouver/ICMJE Style

Mehra R, Jain L. A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India. J Med Allied Sci. (2022), [cited December 04, 2023]; 12(2): 65-69. doi:10.5455/jmas.4045


Harvard Style

Mehra, R. & Jain, . L. (2022) A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India. J Med Allied Sci, 12 (2), 65-69. doi:10.5455/jmas.4045


Turabian Style

Mehra, Rupanshu, and Lalit Jain. 2022. A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India. Journal of Medical and Allied Sciences, 12 (2), 65-69. doi:10.5455/jmas.4045


Chicago Style

Mehra, Rupanshu, and Lalit Jain. "A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India." Journal of Medical and Allied Sciences 12 (2022), 65-69. doi:10.5455/jmas.4045


MLA (The Modern Language Association) Style

Mehra, Rupanshu, and Lalit Jain. "A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India." Journal of Medical and Allied Sciences 12.2 (2022), 65-69. Print. doi:10.5455/jmas.4045


APA (American Psychological Association) Style

Mehra, R. & Jain, . L. (2022) A comparative study of novel inflammatory markers (High sensitivity C-reactive protein and Lipoprotein A) and LDL/HDL cholesterol ratio in acute coronary syndrome at tertiary care center in Central India. Journal of Medical and Allied Sciences, 12 (2), 65-69. doi:10.5455/jmas.4045


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