Abstract
Obesity has emerged as a risk factor for the Chronic kidney disease (CKD). Recent research propose novel obesity indices like Lipid accumulation product (LAP), Visceral adiposity index (VAI), Cardiometabolic index (CMI) to be associated with CKD risk. We aimed to evaluate the association between novel obesity indices and CKD risk indicators such as estimated glomerular filtration rate (eGFR), urine albumin excretion. Anthropometry measures, plasma lipids, eGFR estimation from serum creatinine and urine albumin creatinine ratio (urine ACR) were performed in 60 apparently healthy adults visiting the health checkup clinic. The subjects were divided based on Body mass index (BMI) as non-obese (n=22) and obese (n=38) groups. Their eGFR and urine ACR were compared using independent t-test or Mann-Whitney test. Spearman correlation test determined the association of obesity and lipid indices with eGFR, urine ACR. Anthropometric measures - BMI, WC (waist circumference), lipid indices - TC/HDLc, LDLc/HDLc ratios, and obesity indices - LAP, CMI were significantly higher in the obese group (p<0.05), while their HDLc levels remained low (p<0.05). eGFR and urine ACR were not significantly different between the study groups. Urine ACR of the study population had significant correlation only with BMI (r=-0.337, p=0.038), Waist-hip ratio (r=-0.386, p=0.017), LAP (r=-0.357, p=0.028); whereas eGFR had no remarkable correlations with any of the obesity indices. There were no significant adverse changes in CKD risk markers of obese subjects. Our findings disprove the association of novel obesity indices with CKD risk markers in obese South Indians, thereby invalidating the utility of these novel obesity indices to predict early CKD risk.

Key words: Cardiometabolic index, Chronic kidney disease, Lipid accumulation product, Obesity, Visceral adiposity index